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The safety and pharmacokinetic properties of ivermectin were further assessed in a multiple-dose clinical pharmacokinetic study involving healthy volunteers. In vitro studies using human liver microsomes and recombinant CYP450 enzymes have shown that ivermectin is primarily metabolized by CYP3A4. Compounds of the class bind selectively and with high affinity to glutamate -gated chloride ion channels which occur in invertebrate nerve and muscle cells.

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Tolerance to ivermectin is generally excellent, but serious adverse effects, especially encephalopa-thy, can occur, principally in more heavily infected individuals. Onchocerciasis The impact of 5 years of annual community treatment with ivermectin on the prevalence of onchocerciasis and onchocerciasis-associated morbidity in the village of Gami Central African Republic has been assessed. In a Stromectol pill Without Prescription of the Stromectol pill Without Prescription of ivermectin on Stromectol pill Without Prescription Onchocerca worms the following regimens were compared: There was no difference between the two groups of patients who were treated yearly.

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